Structural and biomechanical characterizations of porcine myocardial extracellular matrix

Structural and biomechanical characterizations of porcine myocardial extracellular matrix.

Extracellular matrix (ECM) of myocardium plays an important role to maintain a multilayered helical architecture of cardiomyocytes. In this study, we have characterized the structural and biomechanical properties of porcine myocardial ECM. Fresh myocardium were decellularized in a rotating bioreactor using 0.1 % sodium dodecyl sulfate solution. Masson's trichrome staining and SEM demonstrated t...

Thermal synthesis of Hematite nanoparticles: Structural, magnetic and morphological characterizations

Hematite (α-Fe2O3) nanoparticle was synthesized using organometallic compound - ferrocene carboxaldehyde through solventless solid state thermal decomposition technique. The crystal structure, magnetic and morphological properties of the decomposed material were studied using powder X-ray diffraction (XRD), superconducting quantum interference device (SQUID) magnetometry, ...

Myocardial extracellular matrix: an ever-changing and diverse entity.

The cardiac extracellular matrix (ECM) is a complex architectural network consisting of structural and nonstructural proteins, creating strength and plasticity. The nonstructural compartment of the ECM houses a variety of proteins, which are vital for ECM plasticity, and can be divided into 3 major groups: glycoproteins, proteoglycans, and glycosaminoglycans. The common denominator for these gr...

Structural and contractile proteins. Part D. Extracellular matrix.

Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering.

The spatial and temporal scales of cardiac organogenesis and pathogenesis make engineering of artificial heart tissue a daunting challenge. The temporal scales range from nanosecond conformational changes responsible for ion channel opening to fibrillation which occurs over seconds and can lead to death. Spatial scales range from nanometre pore sizes in membrane channels and gap junctions to th...